A: Quick recap on what happens when cheese melts:
You get your slice from the underage hottie, and you notice it looks pretty greasy on top. What you’re seeing is that when mozzarella melts at a high temperature, fat turns into liquid and the protein molecules tighten up and squeeze out that fat, and some water, which is the little greasiness you see on top of your pie.
To get into a little more deetz, how greasy your pizza ends up being has to do with quality of cheese, if it was shredded, and how hot the oven was that it just came out of. Which is why, say, Sbarro (is it gross that I love their pizza?) is gonna be a grease-fest compared to Otto or John’s on Bleecker or pizza in Firenza. High quality cheese like fresh mozzarella will release more water than oil, so you don’t get as much of that oily sheen.
Lucky for us, the show Food Detectives went to 25 different NYC pizza places and blotted away.
They found that, on average, you can take 3.5g of oil off a slice- or about 30 calories… Unfortunately not all that much at the end of the day.
So if you’re doing it for the calorie saving, don’t fool yourself that you can skip the gym for blotting your pizza. But if it makes you feel better cause you can’t stand grease running down your chin and it tends to get on your clothes, then go for it. Happens to the best of us 
